Natural History of Syphilis Primary - 2-6 weeks after infection • Chancre, Regional lymphadenopathy Early Latent ≤ 1 year after infection • Asymptomatic Secondary - 1-2 months after primary syphilis • Rash, Fever, Generalized lymphadenopathy, Mucosal lesions, Alopecia, Hepatitis, Nephritis Late Latent - > 1 year after infection • Asymptomatic Early Neurosyphilis → Late Neurosyphilis Tertiary Syphilis - 2-50 years after infection • Gummatous disease (15%); Cardiovascular syphilis (10%); Ocular syphilis; Otic syphilis; Meningovascular disease, meningomyelitis, general paresis, tabes dorsalis (5%) #Syphilis #timeline #progression #diagnosis #stages
