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diagnosis endocrinology thyroid hyperthyroidism algorithm differential hyperthyroid hypothyroid interpretation tfts tsh workup complications function management pathophysiology pharmacology signs symptoms tests
Thyroid Function Tests (TFTs) and Interpretation • TSH, Free T4, Free T3 • T3 Uptake •
Free T4, Free T3 ... • T3 Uptake ... FTI) • Reverse T3
Laboratory Evaluation of Patients for Thyroid Disease Hyperthyroidism: • Graves disease - TSH low; free T4
in some cases, T3 ... low; free T4 and T3 ... low; free T4 and T3 ... low; free T4 and T3 ... low; free T4 and T3
Approach to the Diagnosis of Hyperthyroidism - Differential Diagnosis and Workup Algorithm • Secondary Hyperthyroidism (↑↔TSH,
↑↔TSH, ↑Total T3 ... (↓TSH, ↔Total T3 ... (↓TSH, ↑Total T3 ... (↔TSH, ↔Total T3
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism • Low TSH, Low normal T4
normal T4 +/- T3 ... TSH, high T4 +/- T3 ... TSH, high T4 +/- T3
Pharmaceutical Management of Hyperthyroidism / Thyroid Storm Beta-Blockers • Decreases sympathetic hyperactivity • Partially blocks peripheral conversion
conversion of T4 to T3 ... conversion of T4 to T3 ... conversion ofT4 to T3
Algorithm for the diagnostic workup of hyperthyroidism. (T3 = triiodothyronine; T4 = thyroxine; TSH = thyroid-stimulating
(T3 = triiodothyronine
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 Thyroid Function Test Interpretation Table TSH, Free T4, Free T3 and Associated Condition #Diagnosis #Endocrinology #Hyperthyroid #Hypothyroid #Function
Free T4, Free T3
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
thyrotoxicosis • T3 ... TSH • ↑ Total T3 ... ↑ FT4 and/or ↑ T3 ... : Reduce T4 -> T3
Abnormal Serum TSH - Differential Diagnosis Algorithm Increased TSH • Hypothyroidism • Sub-clinical Hypothyroidism • Recovery from
Thyrotoxicosis • T3
Evaluation of Secondary Hypertension • Primary aldosteronism - PRA, PAC • Renal artery stenosis - Renal
Hypothyroidism - TSH, T3
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