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diagnosis differential dermatology endocrinology alopecia hairloss pruritus secondary systemic hair hashimotos hashitoxicosis hypothyroid iodine loss pathophysiology primary radioactive radionuclide rai
Laboratory Evaluation of Patients for Thyroid Disease Hyperthyroidism: • Graves disease - TSH low; free T4
Disease Hyperthyroidism ... high; in some cases ... scan with focal ... disease course #hypothyroid ... #hyperthyroid #
Hyperthyroidism (low TSH, High T4/T3) - Diagnostic Algorithm Radioactive iodine scan – get if concern for nodular
Hyperthyroidism ... (low TSH, High T4 ... ) - Diagnostic Algorithm ... concern for nodular thyroid ... #Hyperthyroid #
Differentiation of Causes of Hyperthyroidism According to Pattern of Radionucleotide Uptake Reduced uptake: • Thyroiditis • Exogenous
Differentiation of Causes ... of Hyperthyroidism ... loading • Ectopic thyroid ... struma ovarii) Generalized ... hormone stimulation Focal
Hashitoxicosis ‘Leakage’ symptoms of active Hashimoto’s disease - Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
during the initial hyperthyroid ... thyroiditis that causes ... hormone (hyperthyroidism ... enough of it (hypothyroidism ... Diffuse infiltration
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Diagnosis Algorithm ... Endocrine • Hypothyroidism ... • Hyperthyroidism ... contraceptives • Hyperthyroid ... #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Differential Diagnosis Algorithm ... Systemic and Primary Causes ... /uremia TSH & T4 ... #causes
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
Hyperthyroidism ... goiter • Toxic diffuse ... T3 • ↑ Free T4 ... Glucocorticoids: Reduce T4 ... #causes #diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
/uremia TSH & T4 ... : • Hypothyroidism ... • Hyperthyroidism ... secondary #systemic #generalized ... #causes
Diffuse Hair Loss (Alopecia) - Differential Diagnosis Algorithm Scarring - Irreversible-biopsy required • Lupus erythematosus • Lichen
Diffuse Hair Loss ... Differential Diagnosis Algorithm ... • Hyperthyroidism ... contraceptives • Hyperthyroid ... #causes
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Localized / Focal ... Traction alopecia Diffuse ... • Endocrine: Hypothyroidism ... Scaling, pustules, crusts ... deficiency • Thyroid
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