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rheumatology differential management algorithm ana anca antibody antineutrophil antinuclear classification progressive prs pulmonary rapidly rpgn sjogrens syndrome syndromes treatment vasculitides
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Purpura Anti-GBM antibodies ... #Vasculitis #differential ... #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... • EGPA: - Eosinophilia ... tract, and often causes ... C-ANCA) pattern: antibodies ... • Urinalysis (Renal
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ANCA-Associated Vasculitis ... ANCA+ 60% • Eosinophilic ... vasculitis - MPO ... #diagnosis #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... life-threatening diseases ... EGPA) • Auto-antibodies ... LVEF, pericardial effusion ... Goodpasture's cause
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... thickening or effusion ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... acidosis • NAGMA • Glomerulonephritis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... pulmonary and renal ... Polyangiitis): • Eosinophilia ... tract, and often causes ... #Rheumatology
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