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TNF-alpha Inhibitors Dr. Ann Marie Kumfer @AnnKumfer #TNFalpha #Inhibitors #Diagnosis #Differential #Indications
TNF-alpha Inhibitors
TNF-Alpha Inhibitors Pharmacology TNF-a receptor activation produces a nunber of effects that can worsen rheumatoid arthritis (RA).
TNF-Alpha Inhibitors ... Pharmacology TNF-a ... TNF levels are elevated ... soluble recombinant TNF ... drugs bind to TNF-a
The biotrauma hypothesis of ventilator-induced lung injury. IL = interleukin; PEEP = positive end-expiratory pressure; Pplat
plateau pressure; TNF
Fig. 1 Pathophysiology of septic myocardial dysfunction. IL interleukin, iNOS induced nitric oxide synthase, PMN polymorphonuclear
polymorphonuclear cell, TNF
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 Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Azathioprine and/or TNF-α ... azathioprine • TNF-α
Algorithm for managing the failure of anti-TNF therapy. ADA=anti-drug antibody; IM=immunomodulator; MOA=mechanism of action; TNF=tumor necrosis
failure of anti-TNF ... mechanism of action; TNF
Infections in Patients on TNF-alpha Inhibitors - Differential Diagnosis • Viral: VZV, Hep B, Hep C,
in Patients on TNF-alpha
Hypothermia in Sepsis - Pathophysiology • 20% of septic pts → HYPOTHERMIA • Increased mortality 62%
proinflammatory cytokines ↓TNF-α
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
PAF, tryptase, TNF
JAK Inhibitors in 2019 Role in the therapeutic strategy in 2019 • RA: 2nd line after failure
cDMARDS and anti-TNF-apha
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