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diagnosis algorithm treatment pharmacology criticalcare gastroenterology cardiology checklist peds table differential medications pediatrics pulmonary covid19 primarycare guidelines clinical syndrome comparison
Algorithm for managing the failure of anti-TNF therapy. ADA=anti-drug antibody; IM=immunomodulator; MOA=mechanism of action; TNF=tumor necrosis
failure of anti-TNF ... mechanism of action; TNF ... necrosis factor #Management
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Azathioprine and/or TNF-α ... azathioprine • TNF-α ... Syndrome #Treatment #management
Esophageal Crohn's Disease Management Algorithm Assess for Active Symptoms and for Stricturing/Fistulizing Disease Stricturing DX: • Bx r/o
Crohn's Disease Management ... Endo • Anti-TNF ... Crohns #Disease #Management
JAK Inhibitors in 2019 Role in the therapeutic strategy in 2019 • RA: 2nd line after failure
cDMARDS and anti-TNF-apha ... #Rheumatology #Management
Persistent UC Symptoms Despite 5-ASA Therapies • Assess for Drug Adherence • Disease Activity Assessment (bloody
Thiopurines - Anti-TNF ... Refractory #Treatment #Management
Orofacial Granulomatosis - Diagnosis and Management Algorithm Idiopathic OFG: isolated swelling of the lips, BX+ non-caseating granuloma Melkersson-Rosenthal
Diagnosis and Management ... Biologic (Anti-TNF ... Granulomatosis #Diagnosis #Management
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Elevated IL-18, IL-6, TNF-a ... rheumatology #diagnosis #management
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Biologics: Anti-TNF ... Arthritis #diagnosis #management
Fever vs Hyperthermia Fever: • Regulated in the hypothalamic thermoregulatory center • "Set point" raised by prostaglandin
Cytokines (IL-1, TNF-a1pha ... comparison #diagnosis #management
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
macrophages secrete TNF-α ... TNF-α promotes the ... Treatment With TNF ... TB #Diagnosis #Management
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