1119 results
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
- Positive: CD2 ... , CD3, CD8 - Loss ... of CD5 and/or CD7 ... Rarely can be CD4
The biotrauma hypothesis of ventilator-induced lung injury. IL = interleukin; PEEP = positive end-expiratory pressure; Pplat
plateau pressure; TNF ... #Pathophysiology
Fig. 1 Pathophysiology of septic myocardial dysfunction. IL interleukin, iNOS induced nitric oxide synthase, PMN polymorphonuclear
Fig. 1 Pathophysiology ... polymorphonuclear cell, TNF ... necrosis factor #Pathophysiology
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Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... proinflammatory cytokines ↓TNF-α ... Hypothermia #sepsis #pathophysiology
The pathogenesis of idiopathic pulmonary fibrosis. 1 – In an initiating phase, there is lung alveolar
high levels of TGF-β ... cycle of further TGF-β ... growth factor; TGF-β ... growth factor beta; TNF-α ... #IPF #Pathophysiology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- T-cell - CD7 ... , CD3 Chronic ... - B-cell CD5
Cardiac Myocyte Contractile cycle
 - Ca2+ binds to TnC → TnI is inhibited → conformational change
Ca2+ binds to TnC ... → TnI is inhibited ... the action of TnI ... #Pathophysiology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
PAF, tryptase, TNF ... #Anaphylaxis #pathophysiology
Autoimmune Gastritis - Pathophysiology

Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
Autoimmune Gastritis - Pathophysiology ... Anti-ParietaI Cell, CD4 ... Autoimmune #Gastritis #Pathophysiology
TNF-alpha Inhibitors

Dr. Ann Marie Kumfer @AnnKumfer

#TNFalpha #Inhibitors #Diagnosis #Differential #Indications
TNF-alpha Inhibitors