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diagnosis management symptoms differential endocrinology pathophysiology rheumatology hematology neurology workup causes clinical deficiency gh growthhormone oncology physicalexam serotonin alcohol algorithm
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... rare causes of acromegaly ... overgrowth: • Carpal ... Tunnel Syndrome ... Overproduction #diagnosis #signs
Scapholunate Dissociation The spacing between all carpal bones should be 1-2 mm, look for the "Terry Thomas"
spacing between all carpal ... "Terry Thomas" sign ... spacing between all carpal ... ("Terry Thomas sign ... #Dissociation #TerryThomas
Ramsay Hunt Syndrome - Herpes Zoster Oticus Triad: 1. Ipsilateral facial paralysis 2. Ear pain 3. Vesicles
Ramsay Hunt Syndrome ... in the auditory canal ... Guillain-Barré syndrome ... • Stroke syndromes ... Diagnosis #Symptoms #Signs
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... paresthesias (carpal ... decade → peripheral/acral ... Beckwith Wiedemann syndrome ... Endocrinology #Treatment
Carpal Tunnel Syndrome Compression of median nerve Risk Factors • Obesity • Female gender
Carpal Tunnel Syndrome ... Aromatase inhibitor Treatment ... #CarpalTunnel #Syndrome
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... - Giantism or acromegaly ... expansion (e.g. carpal
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Involvement, Spares DIP, Carpal ... Tunnel, Sicca Syndrome ... Instability, Felty's Syndrome ... #rheumatology #signs
Hypothyroidism – symptoms and signs. Symptoms: Tiredness/malaise, Weight gain, Anorexia, Cold intolerance, Poor memory, Change in appearance, Depression, Poor libido,
– symptoms and signs ... , Deafness Signs ... peripheries, Carpal ... timel syndrome, ... Hypothyroid #Features #Signs
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
thyroid, Sjogren syndrome ... “dropping head syndrome ... - Kearns-Sayre syndrome ... test - Cogan sign ... - Peek sign
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... WBC >100k, + lab signs ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment
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