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hematology hemophagocytic lymphohistiocytosis summary acromegaly behcet dermatology disease endocrinology erythematosus hemeonc heparin hit induced lupus macrophage mas pathophysiology polychondritis relapsing
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Liver function tests ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Initial screening test ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
common in Asia • HLA-B51 ... is a skin prick test ... Arthritis, AS Treatment ... #diagnosis #management ... signs #symptoms #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
complex → plt activation ... approach for post-test ... : Confirmatory test ... #Management #Treatment ... #Hematology #HemeOnc
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• A clinical diagnosis ... and lower jaw Treatment ... blockers had the best ... #Rheumatology # ... diagnosis #management
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
and Management ... Beckwith Wiedemann syndrome ... glucose suppression test ... adenoma, ↓(TFT, LH ... #Treatment #Pathophysiology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
/EGPA • RA Diagnosis ... : • Clinical tests ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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