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diagnosis differential hepatology liver transaminitis management rheumatology behcet bronchiectasis causes chemistry classification dili disease druginduced fatigue function hepatocellular interpretation prs
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Liver Function Tests ... Cirrhosis • Chronic ... Viral Hepatitis ... Drug-induced liver injury ... #Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
→ liver test abnormalities ... • Infections: Hepatitis ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... e.g. ascites), Chronic ... hepatitis fibrosis ... #hepatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Differential Diagnosis Algorithm ... Neoplastic / Hematologic ... Epstein-Barr Virus • Hepatitis ... Obstructive Pulmonary ... Fatigue Syndrome
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... > 2 • NASH, Chronic ... : > 3 • Chronic ... • Gilbert's syndrome ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... extrahepatic source - Tests ... : > 3 • Chronic ... #hepatology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
bronchial wall injury ... • Mounier-Kuhn syndrome ... dyskinesia • Young syndrome ... function tests: ... mycobacteria Treatment
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... quantify renal injury ... anti-GBM) Other tests ... pericardial effusion) • PFTs ... diagnosis #management #treatment
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
to local skin injury ... is a skin prick test ... Arthritis, AS Treatment ... Recurrent and chronic ... signs #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... • Cogan Syndrome ... lesions-interstitial keratitis ... retinopathy Lab Tests ... : • CBC • LFT
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