36 results
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing ... in Hemolytic Anemia ... #Laboratory #Testing ... #workup #diagnosis ... #hematology #hemolysis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... - Differential Diagnosis ... hemoglobinuria) • Cold Agglutinin ... Disease Mixed-type ... #Table #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
anemia • Cold ... Test: Donath-Landsteiner ... test #cold # ... agglutinin #disease ... #hematology #diagnosis
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypothyroid • Liver Disease ... #Macrocytic #Anemia ... #differential #diagnosis ... #algorithm #hematology ... #workup
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Diagnostic Algorithm ... chronic kidney disease ... Underproduction #Algorithm #hematology ... #diagnosis #differential ... #workup
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Hemolysis #Hemolytic #Anemia ... Differential #Causes #Workup ... #Hematology #Diagnosis ... GrepMed Recommended Text
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Abnormal Coagulation Tests ... Abnormal #APTT #Laboratory ... #Hematology #Diagnosis ... #Workup
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
( +/- ) Cold agglutinin ... disease • DAT ... #antiglobulin #test ... Autoimmune #Hemolysis #hematology ... #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Agglutination - Cold agglutinins ... #Algorithm #workup ... #hematology #testing
Gastrointestinal Evaluation of Iron Deficiency Anemia
In patients with anemia, diagnose iron deficiency if:
 • Ferritin <
, diagnose iron ... • Additional laboratory ... disease with serology ... Gastrointestinal #Evaluation #workup ... #diagnosis #gastroenterology