29 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... and Platelet Disorders ... decreased PLT count: CBC ... primary hematologic disorder ... #Platelet #Disorders
Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
/critical-care-nephrology ... Action #Location #Nephrology ... #Pathophysiology ... #Pharmacology
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
AcuteKidneyInjury #AKI #Nephrology ... #Pathophysiology ... #Pharmacology
Mechanisms of thiazide diuretic side effects

Dr. Muner Mohamed @MunerMohamed1

#thiazide #diuretic #pharmacology #pathophysiology #sideeffects #adverseeffects #nephrology
thiazide #diuretic #pharmacology ... #pathophysiology ... adverseeffects #nephrology
Mechanism of Action of Diuretics
Amiloride, Triamterene, Spironolactone
Loop Diuretics
Thiazides
Acetazolamide

#Diuretics #Mechanism #Action #pharmacology #pathophysiology #nephrology
Mechanism #Action #pharmacology ... #pathophysiology ... #nephrology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
relapse of bipolar disorder ... alopecia (unusual), thrombocytopenia ... #SideEffects #Pathophysiology ... #Psychiatry #Pharmacology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Adenosine #Nephron #Pathophysiology ... Sites #Action #nephrology ... #pharmacology
Renal Tubular Disorders

 • Distal Renal Tubular Acidosis (Type 1)
 • Proximal Renal Tubular Acidosis (Type
Renal Tubular Disorders ... Acidosis #Types #pathophysiology ... #nephrology #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Artifact (redo CBC ... • Rheumatic disorders ... following EtOH induced thrombocytopenia
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
IL-2 Muromonab-CD3 ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology