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Pharmacotherapy for Migraine Prophylaxis 

Who is indicated for migraine prophylaxis? Patients who experience more than 3
despite appropriate acute ... treatment, or those ... contraindications to acute ... #Table #Pharmacology ... #Management #Neurology
Acute Treatment of Migraine
Mild Attacks: NSAIDs, Simple Analgesics
Moderate/Severe Attacks: Triptans, Ditans, Gepants, Ergots
Non-pharmacologic Treatment: Neuromodulation, Rest,
Acute Treatment ... of Migraine Mild ... Gepants, Ergots Non-pharmacologic ... #acute #treatment ... #management #neurology
Migraine Treatment Overview

 • What is a Migraine?
 • Pathophysiology
 • Common Migraine Triggers
 • Diagnosis
Migraine Treatment ... • What is a Migraine ... Prophylactic Treatment ... #pharmacology # ... prophylaxis #neurology
Acute Treatment of Migraine

- BWH Medicine Chiefs @BrighamChiefs

#Migraine #Treatment #management #neurology #headache #medications
Acute Treatment ... of Migraine - ... BrighamChiefs #Migraine ... #Treatment #management ... #neurology #headache
Migraine - Preventative Treatments

 • Anticonvulsants: *Topiramate, *Sodium valproate, Gabapentin, Pregabalin
 • Antidepressants: Amitriptyline, Venlafaxine, Duloxetine,
Migraine - Preventative ... Treatments ... #management #prophylaxis ... #prevention #pharmacology ... #neurology
Prophylactic Migraine Medications

Established Efficacy: 
 • Metoprolol, Propranolol, Timolol, Divalproex, Valproate, Topiramate, Frovatriptan
Probably Effective: 
 •
Prophylactic Migraine ... Cyproheptadine #Migraine ... #prophylaxis #Medications ... #pharmacology # ... EBM #neurology
Acute ED Migraine Therapy and Preventative Therapy Algorithm:
Acute migraine
 • IV NS IL bolus then infusion
Acute ED Migraine ... Therapy Algorithm: Acute ... 20 mg/min -> Neurology ... management #algorithm #treatment ... #prophylaxis
LOW MOLECULAR WEIGHT HEPARIN (LMWH) DOSING RECOMMENDATIONS (Enoxaparin and Dalteparin):
 - VTE PROPHYLAXIS
 - VTE TREATMENT
Dalteparin): - VTE PROPHYLAXIS ... - VTE TREATMENT ... - ACUTE CORONARY ... Anticoagulation #VTE #Prophylaxis ... #Pharmacology #
Beta Blockers - Pharmacology Comparison Table
Metoprolol:
 • Receptors: β1
 • Indications: Rate control of a-fib/a-flutter, Suppression
Beta Blockers - Pharmacology ... Comparison Table ... Stable angina, Acute ... Essential tremor, Migraine ... bleed prophylaxis
Migraine Prevention and Prophylaxis
Who to Consider: 
 • ≥ 4 significant headaches or migraine attacks/month
 •
and Prophylaxis ... Contraindications to acute ... migraine treatments ... #treatment #prevention ... #prophylaxis #neurology