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rheumatology hematology hemophagocytic hlh lymphohistiocytosis aosd autoimmune dermatology differential disease dress erythematosus hemeonc lupus macrophage mas myopathy myositis onset sle
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... arthritis (sJIA) • Adult-onset ... Petechial or purpuric rash ... #Syndrome #Diagnosis ... #Management #Hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... with urticarial rash ... maculopapular skin ... #Adult #onset ... #rheumatology #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... • Clinical: fever ... diseases: SLE+++, Adult-onset ... #management #treatment
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
rash in association ... Fever >38.5 2. ... withdrawal • Mild ... SinaiBmoreIMRes #DRESS #Syndrome ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... 3rd Decade Skin ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Chronic B-cell activation
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... to find in an adult ... - Common in: Adults ... Pathophysiology ... Fever b.
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... cancer-associated adult ... Symptoms: • Gottron rash ... : Fever, joint pain
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