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rheumatology disease treatment adultonset differential abdominal activation autoimmune causes chronic dermatology dress erythematosus gastroenterology hematology hemophagocytic hlh lupus lymphohistiocytosis macrophage
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... maculopapular rash ... : high fever, CRP ... #management #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... maculopapular skin ... #Adult #onset ... #AOSD #diagnosis ... #rheumatology #management
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... Arthralgia/arthritis, Skin ... rash ± odynophagia ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... Petechial or purpuric rash ... erythematosus [SLE], AOSD ... #Diagnosis #Management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
rash in association ... Fever >38.5 2. ... withdrawal • Mild ... SinaiBmoreIMRes #DRESS #Syndrome ... #management
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
- Differential Diagnosis ... Red Flags: • Fever ... Back pain • Skin ... appendages • FMF • Adult ... Still's disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Clinical: fever ... diseases: SLE+++, Adult-onset ... Still disease, ... #management #treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... 3rd Decade Skin ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... Still disease,
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... cancer-associated adult ... Symptoms: • Gottron rash ... : Fever, joint pain
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