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rheumatology aosd disease hematology hemophagocytic hlh lymphohistiocytosis stills treatment activation adultonset dermatology differential dress erythematosus hemeonc lupus macrophage mas myopathy
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... likely conditions (autoimmune ... : High spiking fever ... maculopapular rash ... #management #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... with urticarial rash ... maculopapular skin ... #Adult #onset ... #rheumatology #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
rash in association ... Fever >38.5 2. ... withdrawal • Mild ... SinaiBmoreIMRes #DRESS #Syndrome ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... disease • Periodic fever ... - Nonremitting fever ... Petechial or purpuric rash ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... 3rd Decade Skin ... Differential Diagnosis ... rheumatoid arthritis, adult-onset ... to: Arthritis, Fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Clinical: fever ... solid cancers • Autoimmune ... diseases: SLE+++, Adult-onset ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
to find in an adult ... - Common in: Adults ... Malignancies ▪ Autoimmune ... Pathophysiology ... Infections, malignancy, autoimmune
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
- Anasarca - Fever ... mesothelioma, etc - Autoimmune ... disease, severe fever ... cell lymphoma Pathophysiology ... #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... cancer-associated adult ... Symptoms: • Gottron rash ... : Fever, joint pain
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