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rheumatology dermatology dermatomyositis symptoms antimda5 antimda5dm antinxp2 antinxp2dm autoimmune differential foot lupus management moccasin myopathy myositis pathophysiology pm polymyositis sle
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... #signs #symptoms
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... with edema • Erythematous ... rash on the face ... auricular papules Clinical ... #dermatology #diagnosis
Moccasin-variety Tinea Pedis 70 M chronic scaly feet. Over the years: rash has itched only occasionally;
Over the years: rash ... Diagnosis? ... . pruritic, erythematous ... skin of inflamed ... Variety #type #clinical
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Pathogenesis and clinical ... processes occur in the skin ... -> Heliotrope Rash ... Pathophysiology #Signs ... #Symptoms #Vasculitis
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
DM with generalized ... to have typical DM ... rash on the face ... auricular papules Clinical ... Dermatomyositis: • ILD
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... elevated < PM and DM ... the spine) or head
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