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diagnosis hematology stills adultonset aosd differential product reactions syndrome vasculitis activation antinxp2 antinxp2dm capnocytophaga classification clinical dermatology dermatomyositis fulminans hemophagocytic
Acute Purpura Fulminans Skin Rash on Physical Exam 60 year old male ITP s/p splenectomy 1d
Skin Rash on Physical ... Exam 60 year old ... Your blood cxs identify ... BIDMC Infectious Diseases ... #photo
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Arthralgia/arthritis, Skin ... rash ± odynophagia ... #diagnosis #management ... #treatment #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... lesions, palpable purpura ... Arthritis, AS Treatment ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... maculopapular skin ... Treatment - Mild ... AOSD #diagnosis #rheumatology ... #management
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... maculopapular rash ... #AOSD #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... rash) • Heart, ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
mucositis - Rash ... VASCULITIS: • Behçet ... pulses, bruis, or blood ... Large Vessel: Blood ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, ischemic skin ... pulses, bruits, or blood ... , mucositis • Rash ... vasculitis • Behcet ... Differential #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... : SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Post Transfusion Purpura ... Causes purpura & ... infections with skin ... Transfusion #diagnosis #management
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