12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... IgA nephropathy, Henoch-SchonIein ... ANCA (C-ANCA): GPA ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... Differential Diagnosis ... • Henoch-Schönlein ... purpura • Mixed cryoglobulinemia ... #dermatology #rash
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... • Henoch Schönlein ... Sarcoidosis • GPA ... #differential #diagnosis
Henoch Schonlein Leg Rash - Palpable Purpura
Purpura: Low Platelets or Vasculitis?
45 years old, seen in our
Henoch Schonlein ... Leg Rash - Palpable ... suggestive of Henoch-Schonlein ... later confirmed by skin ... #photo #dermatology
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis)

55 year old male on tuberculosis treatment
Purpura seen in Henoch ... Schonlein Purpura ... (HSP, IgA Vasculitis ... #clinical #photo ... #dermatology #skin
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... reticularis & skin ... Labs/Diagnosis: ... - GPA, EGPA, microscopic ... (Henoch-Schönlein
Algorithm for Diagnosis of the Petechial / Purpuric Rash

Febrile/Toxic, Palpable: 
 - Meningococcaemia, Disseminated Gonococcal Infection,
Algorithm for Diagnosis ... Petechial / Purpuric Rash ... Endocarditis, Henoch-SchönIein ... - Autoimmune Vasculitis ... #Dermatology #Skin
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often present • Henoch ... Schonlein Purpura ... ANCA +MPO) • Cryoglobulinemic ... Vasculitis - Skin ... mucositis - Rash
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential Diagnosis ... infection - RMSF - Henoch ... Schonlein Purpura ... RA, Sjogren's, GPA ... cryoglobulins • Skin
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, mucositis • Rash ... MPO > PR3 60/ GPA ... often present) Henoch ... Schonlein Purpura ... / ANCA + MPO) Cryoglobulinemic