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diagnosis rheumatology differential vasculitis classification dermatology joint systemic activation algorithm arthropathies arthropathy cryoglobulins dermatologic gpa granulomatosis hematology macrophage management mas
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint Pain ... Rash • Human ... infection Malar rash ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Skin ulcers ... reticularis & skin ... (e.g. systemic lupus ... erythematosus ( ... SLE), rheumatoid
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... rash • Erythematous ... Arthritis: • Joint pain ... Seizures • Strokes Skin
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... , Vasculitis, Purpura ... Demyelinating syndromes ... lesions Abdominal pain ... #erythematosus #
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
arthritis - (Reiter’s syndrome ... arthritis - with the skin ... Erythematosus ( ... SLE), should have ... like “butterfly rash
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... burning sensation or pain ... • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #dermatology #rash
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: erythematous nodules ... mucositis - Rash ... such as systemic lupus ... erythematosus, ... vasculitis, and SLE
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... • Fever is the main ... rash) • Heart, ... erythematosus [ ... SLE], AOSD) • Infection
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... : Erythematous nodules ... , mucositis • Rash ... involvement, abdominal pain ... / ANCA + MPO) Cryoglobulinemic
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