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diagnosis rheumatology differential dermatology classification hematology systemic cryoglobulins cutaneous dermatologic granulomatosis joint monoclonal nonpalpable oncology pain palpable paraproteinemias polyangiitis rashes
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Sarcoidosis • GPA ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Skin ulcers ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... erythematosus ( ... SLE), rheumatoid
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... macules • Erythematous ... • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #dermatology #rash
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis - Skin ... : erythematous nodules ... mucositis - Rash ... erythematosus, ... , and SLE) • Urinalysis
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... Petechiae, Palpable purpura ... Urticarial/LCV) - Cryoglobulinemic ... - GPA Cutaneous ... Disease • Cogan syndrome
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... /HSP • Cryoglobulinemia ... Associated - SLE
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes ... #erythematosus #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... rash • Erythematous ... Antiribosomal P, APLA, PAC ... Seizures • Strokes Skin
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... : Erythematous nodules ... , mucositis • Rash ... MPO > PR3 60/ GPA ... / ANCA + MPO) Cryoglobulinemic
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... (Cryoglobulinemic ... WAIHA • CAD • PCH ... to cold IgG • Lupus
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