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diagnosis rheumatology differential classification dermatology sle systemic cryoglobulinemia cryoglobulins dermatologic granulomatosis hematology monoclonal oncology pain paraproteinemias polyangiitis rashes signs symptoms
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... Pain Rash ... Sarcoidosis • GPA ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
surfaces of the joints ... Maculopapular rash ... macules • Erythematous ... • Goodpasture syndrome ... #dermatology #rash
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: erythematous nodules ... vesicular eruption - Joints ... mucositis - Rash ... such as systemic lupus ... erythematosus,
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes ... SLE #systemic #erythematosus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Arthritis: • Joint ... arthropathy • 90% joints ... Antiribosomal P, APLA, PAC ... Seizures • Strokes Skin
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Skin ulcers ... reticularis & skin ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... erythematosus (
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: Erythematous nodules ... vesicular eruption • Joints ... , mucositis • Rash ... MPO > PR3 60/ GPA ... , joint & gut involvement
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Scleromyxedema (CNS+GI+CVS+joints ... WAIHA • CAD • PCH ... to cold IgG • Lupus
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