18 results
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
Tranexamic Acid: ... fibrin-rich clot #Tranexamic
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Tranexamic Acid ... disturbances #TXA #Tranexamic
The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an
Antifibrinolytic Trial): tranexamic ... controlled trial - Tranexamic ... consider giving tranexamic
Management of Anaphylaxis - Interventions
Epinephrine - Bolus, Infusion, Nebulized
Posture
O2
Fluids
Albuterol 
H1-Antihistamines, H2-Antihistamines
Glucocorticoids
Additional Vasopressor
Glucagon
Sugammadex
Methylene blue
Tranexamic acid
ECMO

#anaphylaxis #management #treatment
Methylene blue Tranexamic
Multiple Uses for Tranexamic Acid (TXA) - Evidence Based Indications and Dosing

Trauma < 3 hrs •
Multiple Uses for Tranexamic
Thromboelastography (TEG) Based Management
 - If R time prolonged -> FFP 
 - If MA low
increased -> 1000mg tranexamic
Thromboelastography (TEG) based therapy and Management

If r time prolonged -> FFP
If MA low -> plts/cryoprecipitate (if
increased -> 1000mg tranexamic
Nebulized Tranexamic Acid for acute treatment of stable hemoptysis 

- Mike O'Brien
@MikeEMPharmD

#Pharmacology #EBM #Management #Dosing #Pathophys
Nebulized Tranexamic
Fibrinolysis. 
Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as
., tranexamic acid
Massive Hemoptysis - Differential Diagnosis Framework and Management
Definition: 150-600 mL over 24 hours
Differential Diagnosis:
 • Tracheobronchial:
5) Nebulized Tranexamic