Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis (reduces complement activation → decreasing swelling in w/ hereditary angioedema) • Metabolism: Unknown, small amount of hepatic metabolism • Time to Onset: 5 - 15 minutes • Duration of Action: ~ 2-3 hours • Method of Excretion: Urine Common Uses: Trauma, Epistaxis, Post-partum, ICH/TBI, Hemoptysis, GI Bleeding Side Effects: Hypotension with rapid injection; Nausea, vomiting, diarrhea & abdominal pain; Dizziness, headache & fatigue; Increases risk of seizures; Hypersensitivity & anaphylaxis; Potentially increases venous & arterial thrombotic events; Impaired color vision & visual disturbances #TXA #Tranexamic #Acid #Indications #Pharmacology #hematology
