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diagnosis differential algorithm hepatitisb aclf acute chemistry classification encephalopathy failure gastroenterology grading hepatic hepatitis hepbv indications interpretation nutrition pathophysiology patterns
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Diagnosis and Management ... viremia or have cirrhosis ... HAV immunity; Liver ... Algorithm #Diagnosis #Management ... #Treatment #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Family history of cirrhosis ... or fibrosis • Cirrhosis ... injury (INR > 2 ... mg/dL) or acute liver ... #management #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... months without treatment ... Injury (DILI) ... #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Tests of synthetic function ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... #differential #Hepatology ... #transaminitis
Nutrition in Cirrhosis: Dos and Don’ts Screening: • Patients at risk for RFH-Nutritional Prioritizing Tool • Low
complications of chronic ... of nutrition in chronic ... muscle mass and function ... #diet #management ... #hepatology #pathophysiology
Hepatic Encephalopathy - Diagnosis and Management Summary Definition: • Alteration in brain function manifested by neuropsychiatric symptoms
Alteration in brain function ... • Caused by liver ... Prevalence: At cirrhosis ... data is limited Diet ... #treatment #hepatology
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