19 results
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Smoking, Microbial triggers ... DNA methylation Genetic ... relative with PBC ... Cholestasis #PBC ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... stone, Malignancy, PBC ... Tests of synthetic function ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Diagnosis Algorithm ... - CBD stone, Biliary ... #hepatology #LiverFunctionTests
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... , biliary epithelium ... hepatocellular injury, genetic ... Interpretation #diagnosis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Diagnosis Hepatocellular ... hepatitis, Acute biliary ... Malignancy, 1° PBC ... Acute #algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Tests (LFTs) - Differential ... Diagnosis Framework ... 500-1000): • Genetic ... #Diagnosis #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... #workup #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Diagnosis Algorithm ... Cholangitis (PBC ... - Other biliary ... #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Methotrexate Genetic ... Nonalcoholic fatty liver ... 14 percent) #Diagnosis ... #Differential # ... Hepatology #Cirrhosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... Diagnosis Algorithm ... Neutrophils - Low RBC ... Function Tests ... #Causes #Hematology