16 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... the study) • Triggers ... ATRA treatment Pathophysiology ... Differentiation #Syndrome #APML ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... hyperviscosity syndrome • Triggers ... WBC >100k, + lab signs ... into serum • Triggers ... #diagnosis #management
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
of more of the signs ... re-administration of possible trigger ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management
Intraoperative Hypertension - Guidelines for Crises in Anaesthesia
Hypertension is most commonly due to inappropriate depth of
and hypercarbia as ... reservoir bag and APL ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management
Intraoperative Tachycardia - Guidelines for Crises in Anaesthesia
Tachycardia in theatre is often due to inadequate depth
reservoir bag and APL ... • Also consider ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management
Intraoperative Cardiac Ischaemia - Guidelines for Crises in Anaesthesia

If the patient is unconscious, signs of cardiac
is unconscious, signs ... a 12-lead ECG as ... soon as possible ... Intraoperative #Checklist ... #Diagnosis #Management
Intraoperative Circulatory Embolus - Guidelines for Crises in Anaesthesia
Causes: thrombus, fat, amniotic fluid, air/gas.
Signs: hypotension, tachycardia,
Signs: hypotension ... Also consider if ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management
Local Anaesthetic Toxicity - Guidelines for Crises in Anaesthesia
Signs of severe toxicity:
 • Sudden alteration in
Signs of severe ... tachyarrhythmias may all ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management
Hypotension - Guidelines for Crises in Anaesthesia

Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
reservoir bag and APL ... • Also consider ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management
Intraoperative  Bradycardia - Guidelines for Crises in Anaesthesia
Bradycardia in theatre should not be treated as
reservoir bag and APL ... • Also consider ... Anesthesiology #Anesthesia ... Intraoperative #Checklist ... #Diagnosis #Management