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differential causes classification hematology high hyperkalemia potassium hypersensitivity nephrology reactions aafp acidosis allergic criticalcare definitions extravascular folate folicacid hemolysis homocysteine
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Molecules • Ex: Antibiotic ... thrombocytopenia, Autoimmune Hemolytic ... anemia, Penicillin-induced ... Stevens-Johnson Syndrome ... #Diagnosis #Definitions
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
I - lgE-Mediated ... Hours to Days (Hemolytic ... Anemia) Type ... Classification #Allergy ... #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... ) - HELLP syndrome ... uremic syndrome ... Drugs (Beta lactam antibiotics
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy Mild Reaction - Itching, Minor rash
Pathway for Antibiotic ... I (lgE-Mediated ... , Hemolytic anemia ... #Pathway #Antibiotics ... #Prescription #algorithm
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hematology for workup ... blood loss, Acute hemolysis ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... post-splenectomy, Exercise, Allergic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... isoniazid) • Antibiotics ... One blood cell type ... Workup: • Complete ... #diagnosis #hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the ... Hemorrhage or hemolysis ... of vitamin B12 are ... #Diagnosis #Macrocytosis ... #Workup #AAFP
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Differential Diagnosis ... • NSAIDs • ACE ... Beta blockers • Antibiotics ... - Tumor lysis syndrome ... Failure • SLE • Type
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Differential Diagnosis ... • NSAIDs • ACE ... Beta blockers • Antibiotics ... - Tumor lysis syndrome ... Failure • SLE • Type
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Shock, Severe Anemia ... Ischemia, Compartment Syndrome ... Beta-Agonists, ↑ work ... • Presents as AG ... in Short Bowel Syndrome
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