25 results
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
late adulthood • Diagnosis ... to 8 years Clinical ... IgA and/or IgM, age ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulins are ... : • Clinical triad ... Labs/Diagnosis: ... Cryoglobulins #diagnosis ... classification #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... < 3 months of age ... insulting agent are ... management #treatment #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Lupus Cerebritis Induction ... CNS #neurology #rheumatology
Lateral Knee Intra-articular Corticosteroid Injection 

Lateral knee IA steroid injection. Hint - the fat pads below
below the knee are ... #clinical #video ... #physicalexam # ... procedure #msk # ... orthopedics #sports #rheumatology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... transplantation CLINICAL ... the underlying pathophysiology ... specific therapy, the clinician ... Guillain #Barre #Syndrome
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
skin necrosis (at injection ... SICU > MICU, ♀, ↑Age ... , ESRD Pathophysiology ... : • Clinical Suspicion ... non-heparin A/C if clinical
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Band neutrophils are ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Epidemiology: - Bimodal age ... Clinical Picture ... myasthenia Diagnosis ... immunologic assay - MuSK ... Myasthenia #Gravis #diagnosis
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... 1) 4) Average age ... survival is 93-95% Pathophysiology ... renal failure Clinical ... anterior/posterior MSK