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diagnosis hematology management oncology differential mds myelodysplastic acidosis chronic classification disorders elevation encephalopathy gbs guillain hypertension indications lactate lactic leukemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... CMV) • Epstein-Barr ... anemia Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... skin that are caused ... • Anemia • Aplastic ... Anemia • Bone ... Workup: • Complete
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... • Bone marrow ... Allogeneic stem cell
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment ... Warm AIHA • Bone ... Leukemia #diagnosis #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... family history - Medications ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... candidate) - Bone
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Hypertension - Workup ... evaluation should be done ... Neurologic disorders ... , and Guillain-Barre ... #Hypertension #Workup
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... and cauda equina TREATMENT ... #Syndrome #diagnosis ... #management #neurology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Transplantation including bone ... Electrolyte abnormality, Medication ... the underlying cause ... • Treatment of
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... and pernicious anemia ... antibody that works ... Treatment: • ... #neurology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
the critically ill ... before beginning treatment ... - Compartment syndrome ... 30mmHg) - Severe anemia ... - HIV/HAART medications
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