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differential management physicalexam clinical leukemia mds monoclonal myelodysplastic rheumatology treatment anemia aplastic cancer causes chronic cll dermatology effusions emergencies finger
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential Diagnosis ... Framework HEMATOLOGIC ... sustained over a one-hour ... shoulder pain, collateral ... #differential #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... • Bone marrow ... Myelodysplastic #Syndrome ... Management #treatment #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... megakaryocytic Bone ... the blood and bone ... #diagnosis #hematology ... #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
g/dl LLN B - Bony ... more: • Clonal bone ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... Hypoplastic MDS: • ↓ bone ... • Suggested by bone ... hypoplasia/fatty bone ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... cells - Blood and Bone ... • Headaches, bone ... neutropenia) • Bone ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Warm AIHA • Bone ... • Richter’s Syndrome ... lymphoma • Marginal zone ... #workup #oncology ... #hematology
One and a Half Syndrome on Physical Exam This 28 year old patient presented to clinic with
One and a Half Syndrome ... gaze palsy to one ... result is that one ... the hospital, diagnosed ... #OneAndAHalf #One
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 Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Splenic Marginal Zone ... TMA • Marginal zone ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
- Differential Diagnosis ... Effusions: - Hematologic ... - Aneurysmal bone ... #differential #diagnosis ... #msk #physicalexam
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