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diagnosis gh growthhormone acromegaly diabetes excess feedbackloop management medications overproduction pituitary signs symptoms treatment
Mechanism of Action for Common Diabetes Medications • SGLT2i (Dapagliflozin) • TZD (Pioglitazone) • Biguanides (Metformin)
#Medications #pharmacology ... #pathophysiology ... #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... overgrowth: • Carpal ... signs #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
expansion (e.g. carpal ... #FeedbackLoop #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... decade → peripheral/acral ... malignancy Pathophysiology ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
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