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diagnosis management hematology lupus differential oncology signs sle algorithm druginduced syndrome systemic treatment antimda5 antimda5dm antiphospholipid aplastic apls arteritis arthritis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... - CRP: Usually normal ... • Immunologic Workup ... Management #Summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... lymphoproliferative syndrome Clinical ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Immunologic Workup ... Systemic Lupus Erythematosus ... • Immunologic Workup ... comparison #table #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... (petechiae) • Frequent ... Out Secondary Causes ... Workup: • Complete ... Syndromes #diagnosis #hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Anemia is described ... well as varying clinical ... These causes could ... Normal range11.5
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... result in severe anemia ... immune hemolytic anemia ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... syndrome (MDS) (normal ... megakaryocytes and a normal ... #oncology #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
with edema • Erythematous ... violaceous macules and erythematous ... auricular papules Clinical ... CD8+ ratio are frequently ... Dermatomyositis #rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... around the most frequently ... exogenous, EPO levels: normal ... you’ll do a good workup ... Diagnosis #Algorithm #workup
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... microorganisms or who have frequent ... autoimmune hemolytic anemia ... levels are within normal ... DDX - Other causes
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