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diagnosis hematology clinical disease management msk oncology radiology rheumatology encephalopathy fibroma fracture framework gammopathies joint knee mds mgus monoclonal multiplemyeloma
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Generally affects long bones ... • XR, MRI to ... BrighamChiefs #Bone ... #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... • Bone and joint ... Rule out other causes ... - MRI: inflammation ... diagnosis #management #Dermatology
Osgood-Schlatter Disease - MSK Radiology Imaging Findings: • Infrapatellar fat-pad edema with loss of the patellar tendon
fragmentation and mild bone ... possible secondary ossification ... • MRI is more sensitive ... tibial tuberosity Differential ... marrow edema and bony
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... folate def - Bone ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
g/dl LLN B - Bony ... more: • Clonal bone ... focal lesions on MRI ... Causes of false- ... plasmacytoma, POEMs syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... megakaryocytic Bone ... Aplastic Anemia • Bone ... blood cells in the bone ... blood smear • Bone
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Drug induced - Bone ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #nonpalpable #dermatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Transplantation including bone ... Vascular narrowing on MRA ... Reversible course Differential ... the underlying cause ... with AEDs until cause
Nonossifying Fibroma with Pathologic Fracture - MSK Radiology Imaging Findings: • Cortically based, geographic, lucent lesion with
• MRI demonstrates ... Jaffe-Campanacci syndrome ... Differential diagnosis ... lesion: • Simple bone ... • Aneurysmal bone
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