65 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... Most cases diagnosed ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long bones ... BrighamChiefs #Bone ... #differential #diagnosis ... #causes #hematology
Wrist / Carpal Bones Mnemonic - Some Lovers Try Positions That They Can’t Handle

Proximal Row (Radial
Wrist / Carpal Bones ... Scaphoid → Lunate → Triquetrum ... Wrist #Carpal #Bones ... #Mnemonic #Anatomy ... Orthopedics #Wrist #Diagnosis
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... hyperplasia of bone ... #Workup #Hematology ... #Diagnosis *
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... swelling of the bone ... • Bone and joint ... Rule out other causes ... as the collar bone
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
excessive bone ... turnover -> Incr bone ... Incr (abnormal) bone ... PagetsDisease #pathophysiology ... #diagnosis #signs
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... (CVID, WAS), (neurologic ... candidate) - Bone ... #Differential #Diagnosis ... #hematology
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
Causes of Dizziness ... - Differential Diagnosis ... Media • Temporal Bone ... Dizziness #Vertigo #Neurology ... #Differential #Diagnosis
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... - Differential Diagnosis ... Drugs, Autoimmune, Bone ... #Differential #Diagnosis ... #causes #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... Renal disease - Bone