9 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... - Highest • Bone ... Intestine - Other causes ... ALP #Elevation #Differential ... Diagnosis #Algorithm #hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • softening of bones ... collection with EDTA Pathophysiology ... : • Other causes ... Hyophosphatasia #hepatology
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Fragility Fractures - Differential ... Tumours - See Bone ... Positive Alkaline Phosphatase ... Diagnosis #Algorithm #Orthopedics ... #Causes
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... predispose to other orthopedic ... • Differentiate ... #diagnosis #causes ... #hematology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... damage weakens the bone ... Fractures #msk #orthopedics ... #diagnosis #differential ... #causes #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... : • Alkaline phosphatase ... bile ducts Differential ... diagnosis #workup #hepatology
Delayed Fracture Healing - Non-Union - Malunion - Differential Diagnosis Algorithm

Inflammation (Hours-Days) -> Soft Callus (Days-Weeks)
Delayed Fracture Healing ... Non-Union - Malunion - Differential ... • Excessive bone ... Diagnosis #Algorithm #Orthopedics ... #Causes
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... work properly, leading ... skin that are caused ... blood count with differential ... Syndromes #diagnosis #hematology
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Osteoclast-osteoblast coupled bone ... Fluoroquinolones - Causes ... from GI tract, bone ... #Stages #Orthopedics ... #msk #Staging #pathophysiology