32 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... Neuropathy ALP is critical ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... in GBA1 gene Clinical ... Osteonecrosis, bone ... #Gauchers #Disease
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
evaluation of the clinical ... /or suspicious clinical ... alcohol-related liver disease ... non-alcoholic fatty liver disease ... Abnormal #Algorithm #Hepatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Diagnosis: • A clinical ... sites such as the collar ... bone, breast bone ... osteoarticular and skin disease
Extrapulmonary manifestations of sarcoidosis.
a. Endobronchial cobblestones (a nodular appearance of the tracheal wall mucosa). 
b. Diffuse
cobblestones (a nodular ... Perthes—Jüngling disease ... lesions in the hand bones ... reaction with nodular ... manifestations #clinical
Trachoma: Pathogenesis and clinical findings

 • Environmental Factors -> Bacterial infection is encouraged by poor hygiene
Pathogenesis and clinical ... bacterium • Disease ... from nasal or ocular ... Trachoma #Chlamydia #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... , Biological + Bone ... Assessment • Clinical ... /ml, ↑ LDH • Bone
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
fever syndromes Clinical ... Fever is the main clinical ... CD163 staining of bone ... is found in the bone ... Diagnosis #Management #Hematology
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... extrapulmonary cases Clinical ... decreased reflexes Pathophysiology ... of bacilli to bone ... CMC_IM #Potts #Disease
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
with autoimmune diseases ... Cryofibrinogenemia Clinical ... pulmonary emboli, and ocular ... Diagnosis: • + Clinical ... #rheumatology #hematology