13 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... • softening of bones ... is critical for ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
evaluation of the clinical ... /or suspicious clinical ... presence of metabolic syndrome ... ALP, alkaline phosphatase ... Abnormal #Algorithm #Hepatology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Refeeding Syndrome ... Pathogenesis and clinical ... PO4 -> decr RBC ATP ... Constipation - MSK ... #diagnosis #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
prognosis • Nodular ... lymphocyte predominant (LP ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Clinical Presentation ... Fever is the main clinical ... tests ↑ AST ↑ ALT ... is found in the bone ... Diagnosis #Management #Hematology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Clinical Picture ... Ocular- 50%: Ptosis ... Generalized fatigue - ALS ... Clinical DX: - ... immunologic assay - MuSK
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Mucous membranes • Bone ... poor nutrition Clinical ... mucocutaneous changes, ocular ... • Delusions Ocular ... nonimmune hemolysis MSK
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... surgery, trauma, and bone-marrow ... transplantation CLINICAL ... the underlying pathophysiology ... Guillain #Barre #Syndrome
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Hodgkin Lymphoma - Clinical ... subtypes: - Nodular ... anymore • Routine bone ... classification #hematology
Nonossifying Fibroma with Pathologic Fracture - MSK Radiology
Imaging Findings:
 • Cortically based, geographic, lucent lesion with
Pathologic Fracture - MSK ... necessary in almost all ... Jaffe-Campanacci syndrome ... • Aneurysmal bone ... #mri #clinical