17 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... • XR, MRI to ... Pain #SickleCell #Disease ... #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
more: • Clonal bone ... focal lesions on MRI ... Causes of false- ... amyloidosis Other causes ... MGUS #diagnosis #hematology
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
- MSK Radiology ... fragmentation and mild bone ... • MRI is more sensitive ... patella #clinical #mri ... Radiology #diagnosis #msk
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
PT, aPTT(liver disease ... (CVID, WAS), (neurologic ... bypass), LFT (liver disease ... candidate) - Bone ... #Workup #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Phosphatase: • Other causes
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... Abnormal Osteoclasts cause ... formation MSK ... causes middle ear ... PagetsDisease #pathophysiology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... Rule out other causes ... - MRI: inflammation ... osteoarticular and skin disease ... diagnosis #management #Dermatology
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... extrapulmonary cases ... decreased reflexes Pathophysiology ... of bacilli to bone ... Diagnosis: - MRI
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... super-antigen mediated disease ... Pallidum - Lyme Disease ... MCTD - Bechet disease ... diagnosis #management #neurology
BEE Syndromes - Non-inflammatory Causes

Immune-mediated conditions affecting the Brain, Eye, and Ear

Visual or auditory symptoms in
Non-inflammatory Causes ... and less common diseases ... neuropathy (LHON) plus MRI ... consistent with MS ... BEE #Syndromes #neurology