64 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long bones ... BrighamChiefs #Bone ... differential #diagnosis #causes ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
practices that could cause ... candidate) - Bone ... patients if the cause ... or if a primary hematologic ... #Workup #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • softening of bones ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Algorithm and Causes ... hyperplasia of bone ... #Differential #Causes ... #Workup #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... • Secondary Causes ... Drug induced - Bone ... Differential #Diagnosis #hematology ... #rheumatology #
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
cause quadriplegia ... invade URT & via hematologic ... within GI and URT causes ... CNS and hematologic ... peds #pediatrics #pathophysiology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... Drugs, Autoimmune, Bone ... Differential #Diagnosis #causes ... #hematology
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... be used by the bone ... Most Common Causes ... 1% Most Common Causes ... Hematologic Malignancy
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... • Bone and joint ... Rule out other causes ... SAPHO #Syndrome #Rheumatology ... diagnosis #management #Dermatology
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Pathophysiology: ... Causes: 1) Exfoliative ... #Diagnosis #Dermatology