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diagnosis signs management clinical hematology msk syndrome hepatology cardiology complications differential oncology treatment amyloidosis cardiac disease echocardiogram endocrinology neurology orthopedics
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... collection with EDTA Pathophysiology ... mineralization Symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Phosphate Physical Symptoms ... signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Secondary #Tertiary #pathophysiology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Most common symptoms ... Renal disease - Bone ... symptoms - Pain
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
mechanical loading => Bone ... strain => Bone ... #orthopedics #pathophysiology ... #symptoms #signs
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... #signs #symptoms
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... ) Pathophysiology ... postpartum): • Initial symptoms ... , ↑Tbili/Dbili/AP ... diagnosis #management #pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... rapid onset of symptoms ... chronic onset of symptoms ... Symptoms: • Malaise ... thrombocytosis) CML Symptoms
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Chemistry Tests - AST, ALT ... Metabolism AST and ALT ... Other locations: bone ... clearance - AP ... Bilirubin #Hepatology #Pathophysiology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Boxes in yellow ... suspicious clinical symptoms ... box indicates all ... ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease Pathophsiology ... Osteonecrosis, bone ... Diagnosis #Signs #Symptoms
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