10 results
diagnosis hematology management leukemia signs anemia aplastic apml bulimianervosa chronic cll differential differentiation encephalopathy genetics hearing loss lymphocytic mastoiditis mds
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... Signs/Symptoms ... /Complications: ... Infertility • Decr Bone ... #genetics #pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Transformation: • Complication ... Leukemia #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Warm AIHA • Bone ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... Constitutional Syndromes ... • Suggested by bone ... • Improve the symptoms ... Aplastic #Anemia #oncology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
3: Necrosis of bone ... inner cortical bone ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... Differentiation #Syndrome ... management #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... age 70 years Symptoms ... megakaryocytic Bone ... the blood and bone ... diagnosis #hematology #oncology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Encephalopathy Syndrome ... Transplantation including bone ... Hypercalcemia Etiology ... : • Pathophysiology ... Neurological symptoms
Hearing Loss - Differential Diagnosis Framework Hearing Loss Types: • Conductive • Sensorineural • Mixed Presbycusis is the most common type
Normal: Air > bone ... hearing loss: Bone ... ○ Meningitis complications ... II ○ Susac’s syndrome ... Differential #Diagnosis #otology
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
Bulimia Nervosa: Complications ... • Boerhaave syndrome ... hormone levels cause bones ... #pathophysiology ... diagnosis #signs #symptoms
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