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diagnosis management hepatology rheumatology differential treatment clinical oncology signs liver msk pathophysiology algorithm dermatology workup cirrhosis lfts summary video photo
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Most common symptoms ... symptoms - Pain ... Diagnosis #Algorithm #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
for the liver ALP ... abnormality vs bone ... Transaminase, ALP ... / ULN ALT) / (ALP ... Transaminitis #diagnosis #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... mineralization Symptoms ... Hyophosphatasia #hepatology
Symptoms of Hypophosphatemia • CNS: Seizures, Delirium, Paresthesias, Central & extrapontine myelinolysis, Hallucinations, Fatigue • Hematologic:
Symptoms of Hypophosphatemia ... Hallucinations, Fatigue • Hematologic ... Heart failure • Bones ... Growth retardation, Bone ... Hypophosphatemia #Phosphate #Symptoms
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
phos/ULN ALP) ... specificity to elevated ALP ... GGT/5-NT: ↑ • ALP ... : Bone, First trimester ... #differential #Hepatology
Cirrhosis leading to Chronic Liver Failure - Clinical Signs and Symptoms #Cirrhosis #LiverFailure #Signs #Symptoms #PhysicalExam #Findings
Clinical Signs and Symptoms ... LiverFailure #Signs #Symptoms ... #PhysicalExam # ... Findings #Diagnosis #Hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... rapid onset of symptoms ... chronic onset of symptoms ... Symptoms: • Malaise ... #Leukemia #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
augment synthesis of ALP ... disease - If ALP ... both are normal, ALP ... : Bone, first trimester ... diagnosis #algorithm #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Boxes in yellow ... suspicious clinical symptoms ... box indicates all ... ALP, alkaline phosphatase ... Abnormal #Algorithm #Hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Chemistry Tests - AST, ALT ... Metabolism AST and ALT ... Other locations: bone ... clearance - AP ... AlkPhos #Bilirubin #Hepatology
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