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diagnosis management oncology differential alkaline anemia liver phosphatase workup abnormal aplastic causes classification clinical disorders elevation enzymes essential et fever
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Renal disease - Bone ... symptoms - Pain ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Hyophosphatasia #hepatology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Workup • CNS symptoms ... Returning Traveler’ algorithm ... CTA • Liver lesions ... values supporting hematologic ... Bone marrow biopsy
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... cells - Blood and Bone ... • Headaches, bone ... neutropenia) • Bone ... #Leukemia #Hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
level <3 g/dL • Bone ... g/dL • Clonal bone ... insufficiency, Anemia, and Bone ... disorder • Clonal bone ... #Significance #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... disease - If ALP ... : Bone, first trimester ... differential #diagnosis #algorithm ... #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... suspicious clinical symptoms ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... Hypoplastic MDS: • ↓ bone ... • Suggested by bone ... hypoplasia/fatty bone ... Anemia #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
pylori test (GI symptoms ... candidate) - Bone ... not required in all ... or if a primary hematologic ... Causes #Workup #hematology
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
Hypercellular bone ... When present, symptoms ... • "Vasomotor" symptoms ... • Treatment algorithms ... Summary #treatment #hematology
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