15 results
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
allele of RB1 tumor ... Retinoblastoma Signs / Symptoms ... Retinoblastoma #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... changes, stroke symptoms ... Lysis Syndrome: • Pathophysiology ... TLS #diagnosis #management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... postpartum): • Initial symptoms ... infiltration) Differential ... obgyn #diagnosis #management ... #pathophysiology
Diplopia - Double Vision - Differential Diagnosis Algorithm
Clinical Pearls:
 • Diplopia is almost always binocular.
 •
Double Vision - Differential ... • Neurologic symptoms ... • Aneurysm • Tumor ... #DoubleVision #Differential ... Algorithm #Causes #Ophthalmology
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
overload) Other Symptoms ... Fanconi syndrome • Tumor-induced ... Syndrome #Nutrition #Differential ... #Diagnosis #Pathophysiology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
meningitis), MCC CNS symptoms ... Behcet disease) Differential ... inhibitors • Uveitis- Ophthalmology ... Syndrome #diagnosis #management ... #signs #symptoms
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Diagnosis and Management ... malignancy Pathophysiology ... pancreatic islet cell tumor ... Differential Diagnosis ... Endocrinology #Treatment #Pathophysiology
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
syndrome • Down, Turner ... Keratoconus Signs / Symptoms ... #Keratoconus #pathophysiology ... #ophthalmology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... initiation • Differential ... APML #diagnosis #management
Aortoenteric Fistula - Diagnosis and Management Summary
Epidemiology:
• Uncommon but life-threatening
• Most common site of bowel connection
Diagnosis and Management ... Clinical Signs/Symptoms ... • Should be on differential ... Pathophysiology: ... Management: SURGERY