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diagnosis differential neurology signs management hematology oncology algorithm causes treatment barre chronic endocrinology guillain hemeonc ophthalmology spinalcord cll comparison cord
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... develop leukostasis syndrome ... Fibrinolysis & DIC • Tumor ... lysis syndrome:
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
paraproteinemia, acute ... leukemia Measure ... Insulin/Glucose, Acute ... , Tumor genesis ... Workup #phosphate #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Abdominal Compartment Syndrome ... AIN: Medication, Infection ... • Obstruction (Tumor ... Differential #Diagnosis #nephrology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Pathogenesis and clinical ... herniation or tumour ... #diagnosis #pathophysiology ... #signs #symptoms
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Pathogenesis and clinical ... allele of RB1 tumor ... allele of RB1 tumor ... Retinoblastoma #pathophysiology ... #symptoms
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High acute ... transfusion • Error of injection ... blockers - MCW Nephrology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
• Toxins • Infection ... Lymphomas • Leukemias ... ) • Tumor lysis ... tumor burden) ... associated with any symptoms
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Osteoarthritis - Overuse syndrome ... Seronegative Reactive Syndrome ... - Acute rheumatic ... Hematologic - Leukemia ... - Giant cell tumor
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... weeks without infection ... Physical Exam/Signs ... ’s lymphoma or acute
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