6 results
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... ≥ 8 mg/dL • Potassium ... ICU transfer • Tumor ... MatthewHoMD #TLS #Tumor ... diagnosis #management #oncology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
be treated with IV ... potassium(K) & ... wasting from other causes ... suggests extra-renal causes ... Renin secreting tumor
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
potassium • Beta ... Transfusion reaction - Tumor ... lysis syndrome ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
potassium • Beta ... Transfusion reaction - Tumor ... lysis syndrome ... differential #diagnosis #causes ... #potassium #high
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... Intracellular Urate, Potassium ... Leukemia #Hematology #Oncology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... fever: - Fever + ANC ... afebrile 24-48 h and ANC ... antibiotics TLS (tumor-lysis ... Treat underlying cause