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diagnosis hematology management algorithm neurology workup leukemia anemia chronic classification gastroenterology hemolytic hodgkins lymphocytic lymphoma pain primary rheumatology treatment abnormal
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL Symptoms: ... extramedullary disease ... -> AML: Blast crises ... ) CLL Symptoms: ... #Oncology #Diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... pylori test (GI symptoms ... not required in all ... #Differential # ... #Workup #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... Myeloproliferative disorders ... • Sickle Cell ... Spleen #Enlarged #Differential ... #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... cells can indicate disease ... lymphoproliferative disorders ... diagnosis #workup #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- B symptoms ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... organ-specific signs ... or symptoms (eg ... #Algorithm #Differential ... #diagnosis #hematology
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Insufficiency Addison's Disease ... Infiltrative Disorders ... Lymphoma Metastatic Disease ... cancer • Renal cell ... autoimmune endocrine disorder
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... lymphoid malignancy (CLL ... younger pts) Differential ... significance (MGUS), CLL ... hemolytic #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Lymphoproliferative Disorders ... Conditioning regimen Signs ... EBV viral load, signs ... to 50% of PTLD cases ... #oncology #diagnosis
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