26 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... Prednisone 5mg/kg ... Diagnosis: >3 symptoms ... initiation • Differential ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... : • Pathophysiology ... unless worrisome EKG ... TLS #diagnosis #management
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
Ehlers-Danlos syndrome ... Changes in collagen types ... rubbing • Atopic diseases ... / Symptoms / Complications ... #Keratoconus #pathophysiology
Causes of Peripheral and Central Vertigo
PERIPHERAL VERTIGO
1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
(Wallenberg's syndrome ... most common type ... Syndrome usually ... varying neurologic signs ... Vertigo #Causes #differential
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... meningitis), MCC CNS symptoms ... ) Differential Diagnosis ... #diagnosis #management ... #signs #symptoms
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... • Or brainstem syndromes ... /SYMPTOMS: • CENTRAL ... Signs and symptoms ... sclerosis #diagnosis #management
Syncope is a sudden, transient loss of consciousness, which is thought to be secondary to cerebral
structural heart disease ... carotid sinus syndrome ... syncope (ruling out differential ... further guide management ... orthostatic vital sign
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... Myeloproliferative Disease ... blood count with differential ... progression to AML
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... of diagnosis (e.g ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
Palpitations - Differential Diagnosis Framework

What?
• It is an unpleasant awareness or sensation that the heart is
Palpitations - Differential ... exam • 12-lead ECG ... Hyperthyroidism • Anemia Psychiatric ... AVNRT Red Flag Symptoms ... Palpitations #Cardiology #Differential