12 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... Crohn's disease Palpable ... Antiphospholipid-antibody syndrome ... Sarcoidosis #dermatology ... #differential #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... - Nonremitting fever ... Petechial or purpuric rash ... #Diagnosis #Management ... #Hematology #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... Renal Syndromes ... • Cutaneous: palpable ... hemosiderin laden macrophages ... #management #treatment
Rickettsialpox Eschar

40 homeless male from NY admitted with fever, chills, headache, myalgias. Diagnosis?
Rickettsialpox R akari classic
Diagnosis? ... Palpable draining ... of R akari is macrophage ... rakari #clinical #photo ... #skinrash #dermatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... Vasculitis: • Fevers ... and branches • Fever ... , mucositis • Rash
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
extensive skin rash ... Fever >38.5 2. ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis ... #management
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with excessive macrophage ... following: • Fever ... #management #treatment ... #hematology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
and Management ... dysregulation: activated macrophages ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary ... #Management #Signs
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Coronary arteries - Fever ... mucositis - Rash ... Vasculitis: • Fevers ... scleritis • Palpable ... Skin -> causing palpable
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Imaging: CXR- pulmonary ... Differentiation #Syndrome ... #management #hematology